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In fact he could easily be described as a one man Delta force team because he just moves from location to location, wreaking havoc and running around guns blazing, leaving behind a trail of destruction. There's nothing smooth about how he operates in this film - he's not charming, not devious, not cunning, not smart and most certainly not subtle. ![]() Bond is nothing more than an action hero with luck at every step. The actions of the villains are moronic and their aims and motivations are so underdeveloped that you simply don't care. The storyline is unbelievably predictable but filled with more holes than Swiss cheese. Sure there's some great special effects and fantastic cinematography featuring a montage of some of the most beautiful places on earth, but the plot itself completely ruins anything the film had going for it. Sure there's some great special effects and fantastic cinematography featuring a montage of some of the most People are giving this movie the benefit of doubt purely because of the Bond brand, but the truth is that it makes for poor watching. People are giving this movie the benefit of doubt purely because of the Bond brand, but the truth is that it makes for poor watching. P.S writings on the wall was a masterpiece and smith deserved all the recognition. The cinematography is beautiful and the soundtrack was stellar ,not to mention some of the best action set pieces & sequences I've seen in a while especially the opening however it could have benefited from being at least twenty minutes shorter ,two hours and thirty minutes is a lot to ask for today's generation to sit through Definitely the second best bond in the Craig trilogy in my opinion. While skyfall was amazing from a directorial standpoint it just felt bland and had no energy whereas here I felt like Craig was bond once again and was having fun in the role and eproved himself again to be the awesome spy we grown to love this decade. While skyfall was amazing from a directorial standpoint it just felt bland and had no energy whereas here I felt like Craig was bond once again and was having fun in the role and eproved Unpopular opinion but I prefer this over skyfall. Unpopular opinion but I prefer this over skyfall. The action scenes are a snoozefest due to poor editing and low stakes, and the monochromatic cinematography makes every location look the same (except for the opening sequence in Mexico, the only one with a wide color palette). Most shockingly, it's not even an interesting movie in the visual departments. How are we supposed to take him seriously when his catchphrase is "cuckoo"? Not to mention his twists are insulting to the audience's intelligence and seem taken from Austin Powers in Goldmember. Christoph Waltz is the same over-the-top cartoonish villain he plays in most of his films, and his motivations are pretty silly. All while Seydoux tries too hard to be sexy and cool, and I'm sorry, but she's no Eva Green or Honor Blackman. Daniel Craig and Lea Seydoux have to go through a forced and chemistry-free romantic subplot that adds nothing to the picture. We're back to the old days when women are one-dimensional plot devices and sexual interests rather than actual characters with personalities and arcs. Ironically, it makes you wonder if Bond still has a place in the contemporary world. The paper-thin story is basically a poor man's Captain America: The Winter Soldier (it revolves around privacy invasion to defend security), and it keeps with the Skyfall tradition of insisting that James Bond is still super relevant in the internet era despite relying on pandering throwbacks to the previous films to drive the point home. ![]() So long for the days when Bond had development and complexity. It's the Diamonds are Forever of the Daniel Craig era in the way that it's a Roger Moore era movie but with a different actor. So long for the SPECTRE grabs everything Casino Royale did to get 007 back on track and flushes it down the toilet. SPECTRE grabs everything Casino Royale did to get 007 back on track and flushes it down the toilet. Central to this challenge is that there are few known proteins that are expressed only on the surface of cancer cells and not on the surface of healthy cells. In our second poster, we presented an approach to addressing the second challenge of finding antibodies that are highly specific to cancer cells. This panel offers unmatched diversity of binding properties and binding locations, excellent developability and is highly differentiated from commonly used molecules. First, we have built what we believe to be by far the industry's largest collection of CD3 binders with more than 500 unique antibodies. Key results from this poster as are as follows. One of our posters that at ACR demonstrated data on our newly generated CD3 panel and its use in building optimized TCEs against to cancer targets EGFR and PSMA. Carl Hansen explained the following on the conference call in his prepared remarks: This catalog of antibodies, AbCellera claims, is by far the largest in the world of its kind and the breadth, speed and diversity of the panel may in fact be groundbreaking in the treatment of cancer.ĬEO Dr. These data show that the company, using its platform and with relative ease I may add, has been able to gather, catalog and analyze over 500 unique and potent bi-specific antibodies that appear to be comparable, or superior to clinical benchmarks. Under the surface however, the company continues to deliver on exactly what management has been telegraphing for some time now, fireworks to come from the pre-partnered programs effort, specifically, the T-cell engager programs.ĭuring the quarter, the company presented a trove of data highlighting the progress of the T-cell engager technology development effort it is currently pursuing. Not a stellar quarter for headlines in newsfeeds. The company only signed one new partnership, adding 3 new programs during the quarter, while the company reported that AbCellera partner, Teva Pharmaceutical ( TEVA), advanced a neurology molecule, discovered by AbCellera, into the clinic during the quarter, the company also reported no new program starts and the cash balance shrunk by over $90 million to $824 million. The first quarter, on the surface, appeared to be a rather boring and unproductive affair. In this article, I would like to dive into the quarter, specifically, the conference call around the TCE programs and explain my continued bullishness for the future. In the first quarter, AbCellera continued to deliver positive business momentum, only to be rewarded with further deep, on paper, shareholder losses. Investing has a sadistic way of making you feel like you are the man in the above photo, with a massive pot of gold hiding somewhere in a vast labyrinth of wrong turns and dead ends.īeing a shareholder of AbCellera Biologics ( NASDAQ: ABCL ) over the last few years, I would argue, has been equally as frustrating however, I would also argue that the last few years have been nothing short of a tremendous success for the company itself from an "under the hood" business perspective. |
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